Expell™ displacers provide rapid protein purification with displacement chromatography.

(Austin, TX) – March 26, 2008 – SACHEM’s Expell™ displacers are featured in the February issue of American Biotechnology Laboratory.  The article is titled “Displacement Chromatography for Rapid Protein Purification in the Laboratory.”

The article outlines the benefits of using commercial displacers, such as SACHEM’s Expell™ to obtain efficient protein separations at very high loadings.  Expell™ displacers offer a simple way to convert analytical chromatography columns into effective tools for obtaining 100+ mg quantities of purified proteins in a single run.  Barry Haymore, Director, New Technology Development and co-author says, “The process turns analytical columns into serious preparative tools and is simple enough to use every day.”

Rosemary Hoffman, Director, Biotechnology Solutions Group and co-author states, “Scientists involved with the preparation and purification of material for toxicology and early-stage clinical trials will often find displacement chromatography superior to FLASH and normal elution chromatography.”

Protein and peptide purification in the laboratory typically requires several time and labor intensive steps. Displacement chromatography (DC) provides a rapid and convenient process for purification on the 100 mg/run scale.  DC purification can be run with commonly available HLPC instrumentation equipped with a large-volume sample loop and fraction collector.  Commercially available high purity displacers simplify the entire process.  The final product is obtained more quickly and more concentrated than elution chromatography.

SACHEM, Inc. delivers highly pure, precise and innovative chemical solutions designed to solve the most demanding and challenging applications.  For over 50 years SACHEM has provided chemical solutions and services to customers in key markets including electronics, biotechnology, starch modification, polymers, catalysts, pharmaceutical and agricultural chemicals.  Based in Austin, Texas, SACHEM’s expanding worldwide operations include manufacturing and research facilities in North America, Europe and Asia with a global service network and presence spanning over 30 countries.