Article in Chromatography Techniques tells why displacement Chromatography is an indispensable tool for the purification of biomolecules.

Austin, TX – November 10, 2008 – Dr. Charles Little, Principal Chemist at SACHEM, Inc., has authored an article in Chromatography Techniques journal titled, “Displacement Chromatography Comes of Age.”  The article highlights the benefits of displacement chromatography over elution chromatography for the purification of biomolecules.  The article includes a history of elution mode chromatography and displacement chromatography, a process description of the three stages of displacement separation, and a discussion of the benefits and advantages of displacement chromatography.

“Displacement chromatography is very useful in protein purification, oligonucleotide purification, quality assurance, biocomparability, and process control.  As chromatographers we want to understand available purification tools and how to pick the best one for our specific applications,” states Dr. Little. Displacement chromatography is fast becoming an indispensible tool for purification of biomolecules of commercial interest, including oligonucleotides.  It enables a higher degree of purification in fewer steps than most commonly practiced techniques.  Best of all, it requires no specialized equipment or materials other than a high-purity, efficient displacer, and can be practiced on the bench or in the plant.